FreeCol

FreeCol is a 2d open source remake of the original Sid Meier game Colonization on dos. You manage the colonist in the name of the Crown of your country of choice (England, France, The Netherlands, or Spain). Your goal is  to colonize the new world, America or a randomly generated landmass. You home country send you colonist when you amass enough religious support (cross production), you can get Indian to join your colony has well and recruit colonist in your motherland with cold hard cash. The main aspect of the game is managing your colonist inside the various cities of your colonies to establish relations or war with other colony and native.

The graphic are inspired by the second installment of the series civilization.

They recently Released a new version if you want to give it a try. 

Related : FreeCol 0.11 (Indieretronews)